Document 0103
 DOCN  M9490103
 TI    Antiproliferative effects of enediynes on AIDS-derived Kaposi's sarcoma
       cells.
 DT    9411
 AU    Corbeil J; Richman DD; Wrasidlo W; Nicolaou KC; Looney DJ; Department of
       Pathology, University of California San Diego, La; Jolla 92093-0679.
 SO    Cancer Res. 1994 Aug 15;54(16):4270-3. Unique Identifier : AIDSLINE
       MED/94320051
 AB    We have investigated the antiproliferative and cytotoxic effects of
       selected enediynes against three Kaposi's sarcoma (KS) cell lines. The
       enediynes tested were found to be very potent in inhibiting the growth
       of KS cells. Treatment with concentrations of 10(-10) M or less were
       capable of producing 50% inhibition of growth. Furthermore, treatment of
       KS cells with enediynes induced apoptosis in up to 80% of the cells.
       This unique class of antitumor agents has therapeutic potential for the
       treatment of KS.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Antibiotics,
       Aminoglycoside/*THERAPEUTIC USE  Antibiotics,
       Antineoplastic/*THERAPEUTIC USE  Apoptosis  Cell Division/DRUG EFFECTS
       Drug Screening Assays, Antitumor  DNA, Neoplasm/DRUG EFFECTS
       Endothelium/DRUG EFFECTS  Human  Male  Muscle, Smooth, Vascular/DRUG
       EFFECTS  Sarcoma, Kaposi's/COMPLICATIONS/*DRUG THERAPY/PATHOLOGY  Skin
       Neoplasms/COMPLICATIONS/*DRUG THERAPY/PATHOLOGY  Support, Non-U.S. Gov't
       Support, U.S. Gov't, Non-P.H.S.  Support, U.S. Gov't, P.H.S.
       T-Lymphocytes/DRUG EFFECTS  Tumor Cells, Cultured  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).